Onur Eskiocak, Saria Chowdhury, Vyom Shah, Emmanuella Nnuji-John, Charlie Chung, Jacob A. Boyer, Alexander S. Harris, Jill Habel, Michel Sadelain, Semir Beyaz, Corina Amor

Intestinal stem cells (ISCs) regenerate the gut epithelium, but aging reduces this capacity due to senescent cell accumulation. Using senolytic CAR T cells to eliminate these cells improves epithelial integrity and immune function. This approach rejuvenates aged ISCs, enhancing intestinal regeneration and demonstrating the potential of targeted cell therapies in aging.

Todd W. Dowrey, Samuel F. Cranston, Nicholas Skvir, Yvonne Lok, Brian Gould, Bradley Petrowitz, Daniel Villar, Jidong Shan, Marianne James, Mark Dodge, Anna C. Belkina, Richard M. Giadone, Paola Sebastiani, Thomas T. Perls, Stacy L. Andersen, George J. Murphy

This study examined longevity and healthy aging in centenarians by analyzing blood samples and reprogramming cells into induced pluripotent stem cells. Differences between biological and chronological age were assessed, creating a resource to study human resilience and develop new treatments for aging-related diseases.

HaiYang Wang, Zhongwei Huang, Yaelim Lee, XinJie Song, Xingyu Shen, Chang Shu, Lik Hang Wu, Leroy Sivappiragasam Pakkiri, Poh Leong Lim, Xi Zhang, Chester Lee Drum, Jin Zhu, Rong Li

Reproductive aging causes fertility decline due to decreased oocyte quality. Researchers created chimeric follicles by transplanting oocytes into different follicular environments. Young oocytes in aged follicles showed reduced maturation, while aged oocytes in young follicles improved significantly. The young environment enhanced oocyte interaction with somatic cells, improved mitochondrial function, and meiotic chromosome segregation, suggesting potential follicular somatic cell-based therapies for age-related infertility.

Jonas Morin, Yves Rolland, Heike A. Bischoff-Ferrari, Alejandro Ocampo, Kevin Perez

By analyzing UK biobank data for over 500,000 patients and 406 medications, researchers found that most drugs negatively impacted lifespan, likely due to the underlying diseases. However, Sildenafil, Atorvastatin, Naproxen, and Estradiol showed potential lifespan benefits, warranting further investigation.

Kristina Perevoshchikova, Peter O. Fedichev

Aging in species like mice and humans shows exponential mortality rate acceleration. By analyzing DNA methylation (DNAm) in aging mice, researchers identified an aging signature with exponential age dependency, reflecting the Gompertz law. This signature aligns with aging clocks and responds to interventions like caloric restriction. Additionally, a linear DNAm signature indicates global demethylation. Single-cell DNAm data reveal this signature captures the exponential expansion of the state space volume in aging organisms, indicating linearly increasing configuration entropy, likely an irreversible process unaffected by interventions.