Ewa K. Bomba-Warczak, Karen M. Velez, Luhan T Zhou, Christelle Guillermier, Seby Edassery, Matthew Steinhauser, Jeffrey N. Savas, Francesca E. Duncan

Exceptionally stable proteins and macromolecules are discovered in mammalian ovaries and oocytes, essential for reproductive health across the lifespan. These long-lived molecules are linked to both the maintenance and age-related deterioration of reproductive tissues.

Daria Timonina, Genesis V Hormazabal, Indra Heckenbach, Edward Anderton, Lauren Haky, Ariel Floro, Rebeccah Riley, Ryan Kwok, Stella Breslin, Harris Ingle, Ritesh Tiwari, Olga Bielska, Morten Scheibye-Knudsen, Herbert Kasler, Judith Campisi, Marius Walter, Eric Verdin

Disrupted sleep is linked to accelerated aging, demonstrating that lack of sleep causes cellular senescence in mice's adipose tissue, leading to oxidative stress and DNA damage. Poor sleep quality may accelerate aging and increase the risk of age-related diseases by promoting senescence in adipose tissue.

Jun Yang, H. Karimi Kinyamu, James M. Ward, Erica Scappini, Trevor K. Archer

PFI-3 enhances iPSC reprogramming by inducing MET in fibroblasts, upregulating E-cadherin, and reducing ECM gene expression, including collagen.

C. Matthias Wilk, Flurin Cathomas, Orsolya Török, Jessica Le Berichel, Matthew D. Park, George R. Heaton, Pauline Hamon, Leanna Troncoso, Brooks P. Scull, Diana Dangoor, Aymeric Silvin, Ryan Fleischmann, Meriem Belabed, Howard Lin, Elias Merad Taouli, Steffen Boettcher, Markus G. Manz, Julia K. Kofler, Zhenyu Yue, Sergio A. Lira, Florent Ginhoux, John F. Crary, Kenneth L. McClain, Jennifer L. Picarsic, Scott J. Russo, Carl E. Allen, Miriam Merad

Neurodegenerative diseases linked to Langerhans cell histiocytosis (LCH-ND) are caused by mutated myeloid cells compromising the blood-brain barrier, leading to inflammation and neuronal damage in the brain. Targeting MAPK activity and cell senescence reduces these effects and improves neurological outcomes.

Kamil Pabis, Diogo Barardo, Jan Gruber, Olga Sirbu, Kumar Selvarajoo, Matt Kaeberlein, Brian K. Kennedy

Reanalysis of lifespan studies shows that short-lived controls overstate longevity interventions' efficacy. The study suggests a mouse longevity intervention should only be considered with high confidence when control lifespans are close to 900 days or if the final lifespan of the treated group is considerably above 900 days.