Young porcine plasma treatment significantly reverses aging in rats at the epigenetic level, as shown by validated epigenetic clocks for various tissues. The treatment notably reduced the epigenetic ages of blood, heart, liver, and hypothalamus, improved organ function, and shifted IgG N-glycosylation patterns from pro- to anti-inflammatory, indicating a reversal of glycan aging.
Treatment with a selective histone deacetylase (HDAC) 1 and 2 inhibitor in aged mice rejuvenates multiple organ systems
The study identifies a small molecule, Cmpd60, that mimics genetic longevity interventions by inhibiting HDAC1/2. It rejuvenates multiple organs, including kidneys, brain, and heart, and shows promise for healthy aging treatments.
On standardization of controls in lifespan studies
Aging intervention research, involving model organisms like mice and flies, frequently lacks consistent standards and full experimental disclosure, leading to incomparable and incoherent longevity studies. The field could benefit from systematic re-analysis and improved quality control by ensuring consistency in lifespan data.
Q3 2023
Systems Age: A single blood methylation test to quantify aging heterogeneity across 11 physiological systems
A novel epigenetic clock, using blood-based methylation data, assesses aging in 11 specific systems (Heart, Lung, Kidney, etc.), outperforming global measures in predicting system-specific outcomes. This approach identifies unique aging subtypes and may aid in personalized age-related healthcare.
Q3 2023
Light at night and modeled circadian disruption predict higher risk of mortality: A prospective study in >88,000 participants
Exposure to bright light at night, recorded in over 88,000 participants, is linked to higher mortality risk over six years. Disrupted circadian rhythms, indicated by computational modeling, may explain this risk. Minimizing night light exposure and maintaining regular light-dark patterns could promote health and longevity.
Q3 2023
Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration
Cellular senescence in axolotl limb regeneration promotes progenitor cell growth and blastema development via Wnt pathway modulation, as revealed by gain- and loss-of-function studies. This senescence creates a pro-proliferative environment, preventing neighboring cells from becoming senescent.
Q3 2023
Genomic Signatures of Exceptional Longevity and Negligible Aging in the Long-Lived Red Sea Urchin
The genome of the long-lived red sea urchin was analyzed and compared with short-lived species, revealing chromosome rearrangements and expanded gene families linked to immunity, nervous system, and genome stability. Genes under positive selection related to genomic regulation, protein homeostasis, and mitochondrial function suggest mechanisms for maintaining tissue homeostasis, disease resistance, and negligible aging.
Q3 2023
