Reanalysis of lifespan studies shows that short-lived controls overstate longevity interventions' efficacy. The study suggests a mouse longevity intervention should only be considered with high confidence when control lifespans are close to 900 days or if the final lifespan of the treated group is considerably above 900 days.
Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan
Exceptionally stable proteins and macromolecules are discovered in mammalian ovaries and oocytes, essential for reproductive health across the lifespan. These long-lived molecules are linked to both the maintenance and age-related deterioration of reproductive tissues.
Chronically disrupted sleep induces senescence in the visceral adipose tissue of C57BL/6 mice
Disrupted sleep is linked to accelerated aging, demonstrating that lack of sleep causes cellular senescence in mice's adipose tissue, leading to oxidative stress and DNA damage. Poor sleep quality may accelerate aging and increase the risk of age-related diseases by promoting senescence in adipose tissue.
Q4 2023
Nature of epigenetic aging from a single-cell perspective
Epigenetic aging involves both co-regulated and stochastic DNA methylation changes, comparing tissue and single-cell data with development stages and RNA analysis. A new algorithm identifies CpG clusters, offering insights into aging interventions.
Q4 2023
Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration
Neurodegenerative diseases linked to Langerhans cell histiocytosis (LCH-ND) are caused by mutated myeloid cells compromising the blood-brain barrier, leading to inflammation and neuronal damage in the brain. Targeting MAPK activity and cell senescence reduces these effects and improves neurological outcomes.
Q4 2023
The germline regulates longevity and somatic repair in a sex-specific manner
Germline manipulation in turquoise killifish shows sex-specific aging effects: depletion boosts female repair and male lifespan, indicating metabolic rejuvenation and pro-longevity genes, challenging classical evolutionary tradeoffs.
Q4 2023.jpg)
A Fully-Automated Senescence Test (FAST) for the high-throughput quantification of senescence-associated markers
The Fully-Automated Senescence Test (FAST) is an automated, image-based method for quantifying senescence in cultured cells by assessing key markers. It standardizes senescence measurement, supports various cell types and microscopes, and aids in evaluating compounds affecting senescence.
Q4 2023
