Intestinal stem cells (ISCs) regenerate the gut epithelium, but aging reduces this capacity due to senescent cell accumulation. Using senolytic CAR T cells to eliminate these cells improves epithelial integrity and immune function. This approach rejuvenates aged ISCs, enhancing intestinal regeneration and demonstrating the potential of targeted cell therapies in aging.
Association between prescription drugs and all-cause mortality risk in the UK population
By analyzing UK biobank data for over 500,000 patients and 406 medications, researchers found that most drugs negatively impacted lifespan, likely due to the underlying diseases. However, Sildenafil, Atorvastatin, Naproxen, and Estradiol showed potential lifespan benefits, warranting further investigation.
Rejuvenation of Senescent Cells by Low Frequency Ultrasound without Senolysis
Senescent cells treated with low frequency ultrasound (LFU) resume growth and increased motility. LFU induces Ca2+ entry, enhances autophagy, and inhibits mTORC1, reversing several senescence markers. Repeated LFU treatments extend cell replicative limits without altering phenotype. Rejuvenation is enhanced by rapamycin and Rho kinase inhibition but blocked by Sirtuin 1, Piezo1, or TRPV1 inhibition.
Q1 2024
A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine
A synthetic receptor platform was developed to target cell therapies for osteoarthritis (OA) to damaged cartilage. Type II collagen-specific synNotch receptors enabled engineered mesenchymal stromal cells (MSCs) to activate only in response to cartilage degeneration, expressing therapeutic genes, reducing inflammation, and promoting cartilage repair, demonstrating targeted OA treatment potential.
Q1 2024
Differential Responses of Dynamic and Entropic Aging Factors to Longevity Interventions
Aging in species like mice and humans shows exponential mortality rate acceleration. By analyzing DNA methylation (DNAm) in aging mice, researchers identified an aging signature with exponential age dependency, reflecting the Gompertz law. This signature aligns with aging clocks and responds to interventions like caloric restriction. Additionally, a linear DNAm signature indicates global demethylation. Single-cell DNAm data reveal this signature captures the exponential expansion of the state space volume in aging organisms, indicating linearly increasing configuration entropy, likely an irreversible process unaffected by interventions.
Q1 2024
Rejuvenation of aged oocyte through exposure to young follicular microenvironment
Reproductive aging causes fertility decline due to decreased oocyte quality. Researchers created chimeric follicles by transplanting oocytes into different follicular environments. Young oocytes in aged follicles showed reduced maturation, while aged oocytes in young follicles improved significantly. The young environment enhanced oocyte interaction with somatic cells, improved mitochondrial function, and meiotic chromosome segregation, suggesting potential follicular somatic cell-based therapies for age-related infertility.
Q1 2024
