Reanalysis of lifespan studies shows that short-lived controls overstate longevity interventions' efficacy. The study suggests a mouse longevity intervention should only be considered with high confidence when control lifespans are close to 900 days or if the final lifespan of the treated group is considerably above 900 days.
Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan
Exceptionally stable proteins and macromolecules are discovered in mammalian ovaries and oocytes, essential for reproductive health across the lifespan. These long-lived molecules are linked to both the maintenance and age-related deterioration of reproductive tissues.
Chronically disrupted sleep induces senescence in the visceral adipose tissue of C57BL/6 mice
Disrupted sleep is linked to accelerated aging, demonstrating that lack of sleep causes cellular senescence in mice's adipose tissue, leading to oxidative stress and DNA damage. Poor sleep quality may accelerate aging and increase the risk of age-related diseases by promoting senescence in adipose tissue.
Q4 2023
Fundamental equations linking methylation dynamics to maximum lifespan in mammals
Methylation change rates in chromatin state and lifespan show an inverse relationship in a study of 125 mammalian species.
Q4 2023
Unlocking cellular plasticity: Enhancing human iPSC reprogramming through bromodomain inhibition and extracellular matrix gene expression regulation
PFI-3 enhances iPSC reprogramming by inducing MET in fibroblasts, upregulating E-cadherin, and reducing ECM gene expression, including collagen.
Q4 2023
Epistemic uncertainty challenges aging clock reliability in predicting rejuvenation effects
A critique of the epigenetic aging clocks for their high uncertainty in rejuvenation predictions during cellular reprogramming, due to misrepresentation in training data and inconsistent outcomes. It suggests incorporating uncertainty estimates into aging clock models for more accurate assessments.
Q4 2023
