The study identifies a small molecule, Cmpd60, that mimics genetic longevity interventions by inhibiting HDAC1/2. It rejuvenates multiple organs, including kidneys, brain, and heart, and shows promise for healthy aging treatments.
Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction
Young porcine plasma treatment significantly reverses aging in rats at the epigenetic level, as shown by validated epigenetic clocks for various tissues. The treatment notably reduced the epigenetic ages of blood, heart, liver, and hypothalamus, improved organ function, and shifted IgG N-glycosylation patterns from pro- to anti-inflammatory, indicating a reversal of glycan aging.
On standardization of controls in lifespan studies
Aging intervention research, involving model organisms like mice and flies, frequently lacks consistent standards and full experimental disclosure, leading to incomparable and incoherent longevity studies. The field could benefit from systematic re-analysis and improved quality control by ensuring consistency in lifespan data.
Q3 2023
Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration
Cellular senescence in axolotl limb regeneration promotes progenitor cell growth and blastema development via Wnt pathway modulation, as revealed by gain- and loss-of-function studies. This senescence creates a pro-proliferative environment, preventing neighboring cells from becoming senescent.
Q3 2023
Decoding biological age from face photographs using deep learning
FaceAge, a deep learning system, estimates biological age from facial photographs, trained on 58,851 individuals and validated on 6,196 cancer patients. It proved prognostically relevant, showing cancer patients typically appear older than their chronological age, correlating with worse survival. FaceAge enhances end-of-life predictions for palliative care patients and is linked to molecular senescence mechanisms, demonstrating its potential in clinical decision-making beyond cancer.
Q3 2023
A study of gene expression in the living human brain
Gene expression in postmortem human brain tissue differs significantly from that in living tissue, challenging assumptions used in medical research. This discrepancy, not explained by factors like age or medication, suggests postmortem studies may inaccurately represent brain gene expression in life, limiting their usefulness for understanding brain health and disease. Future research should consider these differences for more accurate insights.
Q3 2023
