Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness
Intestinal stem cells (ISCs) regenerate the gut epithelium, but aging reduces this capacity due to senescent cell accumulation. Using senolytic CAR T cells to eliminate these cells improves epithelial integrity and immune function. This approach rejuvenates aged ISCs, enhancing intestinal regeneration and demonstrating the potential of targeted cell therapies in aging.