Intestinal stem cells (ISCs) regenerate the gut epithelium, but aging reduces this capacity due to senescent cell accumulation. Using senolytic CAR T cells to eliminate these cells improves epithelial integrity and immune function. This approach rejuvenates aged ISCs, enhancing intestinal regeneration and demonstrating the potential of targeted cell therapies in aging.
Association between prescription drugs and all-cause mortality risk in the UK population
By analyzing UK biobank data for over 500,000 patients and 406 medications, researchers found that most drugs negatively impacted lifespan, likely due to the underlying diseases. However, Sildenafil, Atorvastatin, Naproxen, and Estradiol showed potential lifespan benefits, warranting further investigation.
Rejuvenation of Senescent Cells by Low Frequency Ultrasound without Senolysis
Senescent cells treated with low frequency ultrasound (LFU) resume growth and increased motility. LFU induces Ca2+ entry, enhances autophagy, and inhibits mTORC1, reversing several senescence markers. Repeated LFU treatments extend cell replicative limits without altering phenotype. Rejuvenation is enhanced by rapamycin and Rho kinase inhibition but blocked by Sirtuin 1, Piezo1, or TRPV1 inhibition.
Q1 2024
Re-activation of neurogenic niches in aging brain
Researchers used single-cell spatial transcriptomics (MERFISH) to map neurogenic niches in young and aged murine brains, finding high PTBP1 levels in glia. Suppressing PTBP1 in quiescent glia reactivated them, converting them into neurons that migrated and became GABAergic neurons. This suggests PTBP1 reduction could induce neuron generation in aged brains, offering therapeutic potential.
Q1 2024
Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brain
In the aging brain of a short-lived killifish, researchers studied the transcriptome, translatome, and proteome. Aging causes a reduction in proteins rich in basic amino acids, independent of mRNA regulation and proteasome activity. Aberrant translation pausing reduces ribosome availability, leading to proteome remodeling. This highlights a vulnerability in the biogenesis of basic DNA/RNA binding proteins, potentially connecting various aging hallmarks.
Q1 2024
A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine
A synthetic receptor platform was developed to target cell therapies for osteoarthritis (OA) to damaged cartilage. Type II collagen-specific synNotch receptors enabled engineered mesenchymal stromal cells (MSCs) to activate only in response to cartilage degeneration, expressing therapeutic genes, reducing inflammation, and promoting cartilage repair, demonstrating targeted OA treatment potential.
Q1 2024
A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring
This study examined longevity and healthy aging in centenarians by analyzing blood samples and reprogramming cells into induced pluripotent stem cells. Differences between biological and chronological age were assessed, creating a resource to study human resilience and develop new treatments for aging-related diseases.
Q1 2024
